One out of five hospitalized adults and one out of three hospitalized children worldwide experience the sudden loss of kidney function leading to the Acute Kidney Failure. Nicotinamide Adenine dinucleotide (NAD), a molecule involved in metabolism thought to be key to the aging process when working with the gene called PGC1 alpha provides protection for the kidneys.

Researchers hypothesized that mitochondria might also be serving as an essential and early target for the various risk factors leading to kidney injury as the kidney is a highly metabolic organ that utilizes mitochondrial metabolism to generate adenosine triphosphate (ATP) that enables it to filter blood and remove toxins from the body.

Researchers prescribed significantly high doses of vitamin B3 nutritional supplements to determine if increasing the level of NAD would accelerate recovery from kidney injury as Vitamin B3 serves as a precursor for NAD. They even identified some new connections between PGC1 alpha and the NAD molecule, and their effects on metabolism.

Journal of Clinical & Experimental Nephrology focuses on the dissemination of the latest  advancements on the current knowledge on all the aspects of Nephrology such as Peritoneal Dialysis, Kidney Diseases, Acute Renal Replacement Therapy, Chronic Kidney Disease, End-Stage Renal Diseases, Lupus Nephritis and Renal Transplantation.

Regards,

Calvin Parker
Journal of Clinical & Experimental Nephrology
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